1,542 research outputs found
Offspring subcutaneous adipose markers are sensitive to the timing of maternal gestational weight gain
peer-reviewedBackground
Excessive maternal weight gain during pregnancy impacts on offspring health. This study focused on the timing of maternal gestational weight gain, using a porcine model with mothers of normal pre-pregnancy weight.
Methods
Trial design ensured the trajectory of maternal gestational weight gain differed across treatments in early, mid and late gestation. Diet composition did not differ. On day 25 gestation, sows were assigned to one of five treatments: Control sows received a standard gestation diet of 2.3 kg/day (30 MJ DE/day) from early to late gestation (day 25–110 gestation). E sows received 4.6 kg food/day in early gestation (day 25–50 gestation). M sows doubled their food intake in mid gestation (day 50–80 gestation). EM sows doubled their food intake during both early and mid gestation (day 25–80 gestation). L sows consumed 3.5 kg food/day in late gestation (day 80–110 gestation). Offspring body weight and food intake levels were measured from birth to adolescence. Markers of lipid metabolism, hypertrophy and inflammation were investigated in subcutaneous adipose tissue of adolescent offspring.
Results
The trajectory of gestational weight gain differed across treatments. However total gestational weight gain did not differ except for EM sows who were the heaviest and fattest mothers at parturition. Offspring birth weight did not differ across treatments. Subcutaneous adipose tissue from EM offspring differed significantly from controls, with elevated mRNA levels of lipogenic (CD36, ACACB and LPL), nutrient transporters (FABP4 and GLUT4), lipolysis (HSL and ATGL), adipocyte size (MEST) and inflammation (PAI-1) indicators. The subcutaneous adipose depot from L offspring exhibited elevated levels of CD36, ACACB, LPL, GLUT4 and FABP4 mRNA transcripts compared to control offspring.
Conclusions
Increasing gestational weight gain in early gestation had the greatest impact on offspring postnatal growth rate. Increasing maternal food allowance in late gestation appeared to shift the offspring adipocyte focus towards accumulation of fat. Mothers who gained the most weight during gestation (EM mothers) gave birth to offspring whose subcutaneous adipose tissue, at adolescence, appeared hyperactive compared to controls. This study concluded that mothers, who gained more than the recommended weight gain in mid and late gestation, put their offspring adipose tissue at risk of dysfunction.This research was funded by Teagasc, under the National Development Plan. LBMcN was in receipt of a Teagasc Walsh Fellowship. Nestle hosted LG on a sabbatical and funded the RT-PCR cost
Performance of a Large-Area GEM Detector Prototype for the Upgrade of the CMS Muon Endcap System
Gas Electron Multiplier (GEM) technology is being considered for the forward
muon upgrade of the CMS experiment in Phase 2 of the CERN LHC. Its first
implementation is planned for the GE1/1 system in the region of the muon endcap mainly to control muon level-1 trigger rates
after the second long LHC shutdown. A GE1/1 triple-GEM detector is read out by
3,072 radial strips with 455 rad pitch arranged in eight -sectors.
We assembled a full-size GE1/1 prototype of 1m length at Florida Tech and
tested it in 20-120 GeV hadron beams at Fermilab using Ar/CO 70:30 and
the RD51 scalable readout system. Four small GEM detectors with 2-D readout and
an average measured azimuthal resolution of 36 rad provided precise
reference tracks. Construction of this largest GEM detector built to-date is
described. Strip cluster parameters, detection efficiency, and spatial
resolution are studied with position and high voltage scans. The plateau
detection efficiency is [97.1 0.2 (stat)]\%. The azimuthal resolution is
found to be [123.5 1.6 (stat)] rad when operating in the center of
the efficiency plateau and using full pulse height information. The resolution
can be slightly improved by 10 rad when correcting for the bias due
to discrete readout strips. The CMS upgrade design calls for readout
electronics with binary hit output. When strip clusters are formed
correspondingly without charge-weighting and with fixed hit thresholds, a
position resolution of [136.8 2.5 stat] rad is measured, consistent
with the expected resolution of strip-pitch/ = 131.3 rad. Other
-sectors of the detector show similar response and performance.Comment: 8 pages, 32 figures, submitted to Proc. 2014 IEEE Nucl. Sci.
Symposium, Seattle, WA, reference adde
A novel application of Fiber Bragg Grating (FBG) sensors in MPGD
We present a novel application of Fiber Bragg Grating (FBG) sensors in the
construction and characterisation of Micro Pattern Gaseous Detector (MPGD),
with particular attention to the realisation of the largest triple (Gas
electron Multiplier) GEM chambers so far operated, the GE1/1 chambers of the
CMS experiment at LHC. The GE1/1 CMS project consists of 144 GEM chambers of
about 0.5 m2 active area each, employing three GEM foils per chamber, to be
installed in the forward region of the CMS endcap during the long shutdown of
LHC in 2108-2019. The large active area of each GE1/1 chamber consists of GEM
foils that are mechanically stretched in order to secure their flatness and the
consequent uniform performance of the GE1/1 chamber across its whole active
surface. So far FBGs have been used in high energy physics mainly as high
precision positioning and re-positioning sensors and as low cost, easy to
mount, low space consuming temperature sensors. FBGs are also commonly used for
very precise strain measurements in material studies. In this work we present a
novel use of FBGs as flatness and mechanical tensioning sensors applied to the
wide GEM foils of the GE1/1 chambers. A network of FBG sensors have been used
to determine the optimal mechanical tension applied and to characterise the
mechanical tension that should be applied to the foils. We discuss the results
of the test done on a full-sized GE1/1 final prototype, the studies done to
fully characterise the GEM material, how this information was used to define a
standard assembly procedure and possible future developments.Comment: 4 pages, 4 figures, presented by Luigi Benussi at MPGD 2015 (Trieste,
Italy). arXiv admin note: text overlap with arXiv:1512.0848
Development and performance of Triple-GEM detectors for the upgrade of the muon system of the CMS experiment
The CMS Collaboration is evaluating GEM detectors for the upgrade of the muon system. This contribution will focus on the R&D performed on chambers design features and will discuss the performance of the upgraded detector
Overview of large area triple-GEM detectors for the CMS forward muon upgrade
In order to cope with the harsh environment expected from the high luminosity LHC, the CMS forward muon system requires an upgrade. The two main challenges expected in this environment are an increase in the trigger rate and increased background radiation leading to a potential degradation of the particle ID performance. Additionally, upgrades to other subdetectors of CMS allow for extended coverage for particle tracking, and adding muon system coverage to this region will further enhance the performance of CMS
Charged particle detection performance of Gas Electron Multiplier (GEM) detectors for the upgrade of CMS endcap muon system at the CERN LHC
The Compact Muon Solenoid (CMS) detector is one of the two general-purpose detectors at the CERN LHC. LHC will provide exceptional high instantaneous and integrated luminosity after second long shutdown. The forward region |η| ≥ 1:5 of CMS detector will face extremely high particle rates in tens of kHz/cm2 and hence it will affect the momentum resolution, efficiency and longevity of the muon detectors. Here, η is pseudorapidity defined as η = -ln(tan(θ/2)), where θ is the polar angle measured from z-axis. To overcome these issues the CMSGEM collaboration has proposed to install new large size rate capable Triple Gas Electron Multiplier (GEM) detectors in the forward region of CMS muon system. The first set of Triple GEM detectors will be installed in the GE1/1 region (1:6 <; |η| <; 2.2) of the muon endcap during the long shutdown 2 (LS2) of the LHC. Towards this goal, full size CMS Triple GEM detectors have been fabricated and tested at the CERN SPS, H2 and H4 test beam facility. The GEM detectors were operated with two gas mixtures: Ar/CO2 (70/30) and Ar/CO2/CF4 (45/15/40). In 2014, good quality data was collected during test beam campaigns. In this paper, the performance of the detectors is summarized based on their tracking efficiency and time resolution
Quality control and beam test of GEM detectors for future upgrades of the CMS muon high rate region at the LHC
Gas Electron Multipliers (GEM) are a proven position sensitive gas detector technology which nowadays is becoming more widely used in High Energy Physics. GEMs offer an excellent spatial resolution and a high particle rate capability, with a close to 100% detection efficiency. In view of the high luminosity phase of the CERN Large Hadron Collider, these aforementioned features make GEMs suitable candidates for the future upgrades of the Compact Muon Solenoid (CMS) detector. In particular, the CMS GEM Collaboration proposes to cover the high-eta region of the muon system with large-area triple-GEM detectors, which have the ability to provide robust and redundant tracking and triggering functions. In this contribution, after a general introduction and overview of the project, the construction of full-size trapezoidal triple-GEM prototypes will be described in more detail. The procedures for the quality control of the GEM foils, including gain uniformity measurements with an x-ray source will be presented. In the past few years, several CMS triple-GEM prototype detectors were operated with test beams at the CERN SPS. The results of these test beam campaigns will be summarised
Design of a constant fraction discriminator for the VFAT3 front-end ASIC of the CMS GEM detector
In this work the design of a constant fraction discriminator (CFD) to be used in the VFAT3 chip for the read-out of the triple-GEM detectors of the CMS experiment, is described. A prototype chip containing 8 CFDs was implemented using 130 nm CMOS technology and test results are shown. © CERN 2016
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